Peptide modifications
Modifications are reviewed on a per-project basis rather than offered as a fixed list; feasibility depends on the target sequence, and availability is confirmed on inquiry.
Terminal modifications
N-terminal acetylation and C-terminal amidation are common options for adjusting the stability and charge of a sequence, and are reviewed for each project.
Cyclisation and disulfide bridges
Disulfide bridge formation and other cyclisation strategies can be discussed for sequences where a constrained structure is relevant to the research.
Labelling
Biotinylation and fluorescent labels such as FITC or 5-FAM can be reviewed for sequences intended for detection or binding-assay work.
PEGylation and lipidation
PEGylation and lipidation are reviewed where a project calls for altered solubility or membrane-interaction properties in research use.
D-amino acids and isotopes
D-amino acid substitutions and isotope labelling can be discussed for sequences intended for stability or tracing studies.
Phosphorylation
Site-specific phosphorylation can be reviewed for sequences relevant to kinase and signalling research.
Confirming availability
Because feasibility depends on the sequence and the combination of modifications requested, availability and any impact on purity or lead time are confirmed during feasibility review.